In the year 1862 the college is being renamed 'Polytechnische Schule' (poly-technical college) and academic training takes place in 8 technical and natural science subjects. Institut für Hygiene und Mikrobiologie Josef-Schneider-Straße 2 97080 Würzburg Suche … Arbeitspapiere des Instituts für Marketing, TU Braunschweig The Technische Universität Braunschweig is the academic centre of Braunschweig in the centre of Europe's most active research region. The S2 domain mediates viral fusion with the host … Several databases provide web services via SOAP, such as the major sequence databases (23–25). Additional information, such as kinetic data, operon structures or transcriptomics data are retrieved on-the-fly via web services from PRODORIC, BRENDA and KEGG (Table 2). In the year 1862 the college is being renamed 'Polytechnische Schule' (poly-technical college) and academic training takes place in 8 technical and natural science subjects. We offer teaching, research and transfer with excellent facilities and a personal atmosphere at the same time. Our long term goal is the development of a dynamic model simulating the behaviour of P.aeruginosa during infection. Institut für Fahrzeugtechnik TU Braunschweig Aufsätze in Zeitschriften Nr. Our core research fields are mobility, infections and therapeutics, metrology and the city of the future. Our database comprises information on eight different Pseudomonas species and strains, which genomes have been completely sequenced and functionally annotated. Telefon +49-(0)531-391-5800 Telefax +49-(0)531-391-5854. 2 Technische Universität Braunschweig, Institut für Mikrobiologie, Braunschweig, Germany Helmholtz Centre for Infection Research, Braunschweig, Germany unal@tau.edu.tr m.steinert@tu-bs.de. Ovarian cancer risk score predicts chemo-response and outcome in epithelial ovarian carcinoma patients. Institut für Mikrobiologie, TU Braunschweig Germany . Currently, SYSTOMONAS contains 10 034 proteins identified as enzymes, 195 transcription factor–gene relations, 14 250 measuring points of three independent metabolome experiments. Cell-to-cell fusion is crucial for the development and propagation of most eukaryotic organisms. Gerhard Bringmann. 0313398A), BMBF for the Bioinformatics Competence Center Intergenomics (Grant No. Contact. Corresponding Author. Institut für Pharmazeutische Wissenschaften, Pharmazeutische Biologie und Biotechnologie, Albert-Ludwigs-Universität Freiburg, Stefan-Meier-Str. Es werden keine Bewerbungen mehr angenommen. Kinetic data and corresponding references, Transcription factors, DNA binding sites, and corresponding references, Experimental conditions for expression profile experiments, Expression profiles experiments and corresponding references. 19, 79104 Freiburg, Germany. Technische Universität Braunschweig stands for a strategic and achievement-oriented way of thinking and acting, dedicated teaching, multi-layered networking with our partners in science, industry and society, and intensive international cooperation projects. An abbreviation code for the species is provided with the visualization output (AO1 = P.aeruginosa PAO1, A14 = P.aeruginosa PA14, P = P.putida KT2440, Pf-5 = P.fluorescens F5, F01 = P.fluorescens PfO-1, ST = P.syringae pv tomato, SP = P.syringae pv phaseolicola, SS = P.syringae pv syringae). Both viruses use the human ACE2 receptor for cell entry, recognizing it with the Receptor Binding Domain (RBD) of the S1 subunit of the viral spike (S) protein. Susanne ERNST of Technische Universität Braunschweig, Braunschweig | Read 10 publications | Contact Susanne ERNST For full access to this pdf, sign in to an existing account, or purchase an annual subscription. In particular, the step of plasma membrane merger and the contributing proteins and physicochemical factors remain mostly unknown. The complexity of a systems biology approach requires the focus on a certain well investigated organism. The novel betacoranavirus SARS-CoV-2 causes a form of severe pneumonia disease, termed COVID-19 (coronavirus disease 2019). These pathways can be obtained from metabolic pathway entries. Institut für Technische Mikrobiologie. The advantage of a data warehouse is mainly its fast performance during the data retrieval. First, a restricted BLAST analysis (18) was performed on the protein sequences followed by a pairwise global alignment using the tool stretcher of the EMBOSS package (19). Broad data integration is realized using SOAP interfaces for the well established databases BRENDA, KEGG and PRODORIC. the prediction of the regulation of certain genes by specific transcription factors. The authors are much obliged to Frank Klawonn for advising in the statistical part of metabolomics comparison. It also refers to genome annotation web sites of other Pseudomonas genome projects for the most up-to-date information. Mit 'OK' verlassen Sie die Seiten der Universität Würzburg und werden zu Twitter weitergeleitet. Institut für Konstruktionstechnik - - - 1 Server: LSF19 Imprint and privacy Accessibility Statement QIS and LSF are products of eG Phone: +49 (0) 531 391-0 Interaction of Streptococcus pneumoniae with the surface of endothelial cells is mediated in blood flow via mechanosensitive proteins such as the Von Willebrand Factor (VWF). To develop neutralizing anti-SARS-CoV-2 antibodies, antibody gene libraries from convalescent COVID-19 … The database structure of SYSTOMONAS is suitable for the simple storage of various types of experimental data. Oxford University Press is a department of the University of Oxford. Die Daten dienen dazu, das Webangebot zu optimieren.Weitere Informationen finden Sie in unserer Datenschutzerklärung. Medizinische Hochschule Hannover. Next, we imported KEGG-pathway data and enabled links to pathway maps via the SOAP interface provided by KEGG (9), in which P.aeruginosa enzymes are highlighted. All known metabolic reactions are depicted here for the ‘Urea cycle and metabolism of amino groups’ pathway. Global optimization via the dual SONC cone and linear programming. Street: Langer Kamp 8: Zip-Code: 38106: City: Braunschweig: Website: www.ifs.tu-braunschweig.de: Long Description: The institute of joining and welding of the Technical University of Braunschweig has approximately 60 employees, 35 thereof being scientific staff. The user immediately recognizes enzymatic reactions unique to one Pseudomonas species. Kolloquium 25.11.2015, Landesamt für … Therefore, we searched for all deduced proteins of the SYSTOMONAS database for orthologous proteins in other Pseudomonas species to obtain orthologous protein clusters. Fähigkeiten und Kenntnisse. PGD2, BioCyc, ENZYME also contributed to the functional annotation of enzymes. P. O. Third, if the identity of the global alignment (stretcher) equals or exceeds 60%, all EC number connections to proteins were transferred to their orthologous protein partners. (Redirected from Technische Universität Braunschweig) The Technische Universität Braunschweig (unofficially University of Braunschweig – Institute of Technology), commonly referred to as TU Braunschweig, is the oldest Technische Universität [ de] (comparable to an institute of technology in the American system) in Germany. Working Paper Series, Institut für Finanzwirtschaft, TU Braunschweig Foreign Languages. Braunschweiger Forscher ernten Kartoffeln für die Wissenschaft. Institut für Fahrzeugtechnik, Technische Universität Braunschweig Jan. 2019 –Heute 2 Jahre. Angestellt, Werkstudentin am Institut für Marketing, Technische Universität Braunschweig. Technische Universität Braunschweig Universitätsplatz 2 38106 Braunschweig. Institut für Mikrobiologie. Different colours for rectangles specify distinct Pseudomonas species, which catalyse the corresponding reaction. OK Abbrechen. Several other databases, such as Atlas (26) are organized as data warehouses. All newly detected EC numbers by metaSHARK are also indicated as ‘predicted’ in SYSTOMONAS. Harnessing lymphoma epigenetics to improve therapies (article not eligible for CME credit). Welcome to the website of the Institute for Technical Microbiology The Institute for Technical Microbiology studies microorganisms, the workhorses of classical and modern biotechnology. Institut für Finanzwirtschaft, Technische Universität Braunschweig Collections in this community. Sprachen und interkulturelle Kommunikation, Graduiertenschulen und Graduiertenkollegs, Fakultät Architektur, Bauingenieurwesen und Umweltwissenschaften, Fakultät für Elektrotechnik, Informationstechnik, Physik, Fakultät für Geistes- und Erziehungswissenschaften, Braunschweiger Zentrum für Systembiologie (BRICS). José V. Ramos. Institut für Mikrobiologie Startseite > Mitarbeiter > Prof. Horn ... manipulators of global warming. Zur anonymisierten Webanalyse nutzt die TU Braunschweig die Software Matomo. Hartmut Fricke: Technische … Table 1 lists parts of the corresponding database content. Technische Universität Braunschweig Hans-Sommer-Straße 4 38106 Braunschweig Veröffentlichungen und Institutsberichte Prof. Dr.-Ing. With 20,000 students and 3,700 employees, we are the largest technical university in Northern Germany. Information on transcription factor binding sites can be found for example in RegulonDB (6) or PRODORIC (7), while metabolic reactions or pathways need to be retrieved from other database, such as BRENDA (8), BioCyc (5), KEGG (9), PseudoCyc (10), and UM-BDD (11). 031U110A/031U210A) and the Volkswagen Foundation. MEET US AT THE. 1. RWTH Aachen University | Technische Universität Berlin | Technische Universität Braunschweig | Technische Universität Darmstadt | Technische Universität Dresden | Leibniz Universität Hannover | Karlsruher Institut für Technologie | Technische Universität München | Universität Stuttgart Institut für Organische Chemie. Herzlich Willkommen auf der offiziellen Facebook-Seite der TU Clausthal! The corresponding annotation process is described in the following sections. Claudia Choi, Richard Münch, Stefan Leupold, Johannes Klein, Inga Siegel, Bernhard Thielen, Beatrice Benkert, Martin Kucklick, Max Schobert, Jens Barthelmes, Christian Ebeling, Isam Haddad, Maurice Scheer, Andreas Grote, Karsten Hiller, Boyke Bunk, Kerstin Schreiber, Ida Retter, Dietmar Schomburg, Dieter Jahn, SYSTOMONAS — an integrated database for systems biology analysis of Pseudomonas, Nucleic Acids Research, Volume 35, Issue suppl_1, 1 January 2007, Pages D533–D537, https://doi.org/10.1093/nar/gkl823. This work was funded by the German Bundesministerium für Bildung und Forschung (BMBF) for the National Genome Research Network (NGFN2-EP, grant no. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Our initial focus was on metabolomics. Prof. Dr. rer. 10.06.2010 Rainer Renkawitz Klaus Brehm Institut für Hygiene und Mikrobiologie. Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, D-38106 Braunschweig, Germany. The major advantage of SOAP is its up-to-dateness, since SOAP-transmitted information is corresponding to the most recent data of the consulted database. 16.12.2015 Prof. Christiane Dahl, Mikrobiologie, Universität Bonn 2. With this database we would like to encourage the Pseudomonas community to elucidate cellular processes of interest using an integrated systems biology strategy. Dishi Liu | Braunschweig und Umgebung, Deutschland | Researcher bei Technische Universität Braunschweig, Institut für Wissenschaftliches Rechnen | 53 Kontakte | Vollständiges Profil von Dishi auf LinkedIn anzeigen und vernetzen Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 38106 Braunschweig, Germany Search for more papers by this author Jeroen S. Dickschat Matthias Luttmann Masterand bei Institut für Raumfahrtsysteme, Technische Universität Braunschweig Braunschweig, Niedersachsen, Deutschland 33 Kontakte Herzlich willkommen auf der offiziellen Facebook-Seite der TU Braunschweig! Besides our own experimental metabolome, proteome and transcriptome data, various additional predictions of cellular processes, such as gene-regulatory networks were stored. The 1509 annotated enzymes were retrieved from KEGG (1003), PGDv2 (1017), BioCyc (493), ENZYME (393) and from our own annotation (241). Phone: +49 (0) 531 391-0 If the user is interested in the prediction of transcription factor binding sites and the deduction of corresponding regulons the tool Virtual Footprint (4) can be employed. Rectangles depict metabolic reactions, ellipses represent metabolites whose names are abbreviated with an asterisk * when the length exceeds 10 letters. This makes the Technische Universität the most established and traditional university in Germany. Research; Relationships; 1 August 2019 - 31 July 2020. The visualization of metabolic pathways from KEGG in SYSTOMONAS is based on GraphViz using the dot layout. (4)Institut für Mikrobiologie, Technische Universität Braunschweig; simone.bergmann@tu-bs.de. Comparing a Pseudomonas protein of interest with other well-characterized proteins may deliver useful insights into the evolution, distribution and species specific function. Institut für Gebäude- und Solartechnik, Technische Universität Braunschweig - Intelligent Energy Europe Institut für Zellbiologie und Biophysik. In particular, the step of plasma membrane merger and the contributing proteins and physicochemical factors remain mostly unknown. Principal institution: Department of Life Sciences (FLW), TU Braunschweig. This tool is able to identify potential enzyme-encoding genes in raw DNA sequences, which are not annotated yet. P. O. To reconstruct metabolic networks, we transferred known EC numbers of each Pseudomonas protein to its homologous partners. The Institute for Information Systems at Technische Universität Braunschweig, Germany, focuses on research and teaching in the area of databases and information systems.. 4904 olid siin. Intercultural Communication. If the levels of specific metabolites differ significantly between different conditions, the measured values are found distinct to a fictive diagonal line. nat. Besides other research groups and our own experimental results further data are retrieved from major general data resources. Conflict of interest statement. The EC number source on the website is indicated accordingly. Institut für Marketing, Technische Universität Braunschweig Collections in this community. Start. However, there still exist only a few tools combining both networks such as the Pathway Tools Omics Viewer (5). 1Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Beethovenstraße 55, 38106 Braunschweig, Germany. External web services implemented on the SYSTOMONAS (S.) websites via SOAP. Mareike Dressler. EC numbers newly identified by our method are declared as ‘predicted’. Search for more papers by this author. We have chosen the Gram negative proteobacterium Pseudomonas aeruginosa. We provide SBML (27) formatted files for downloading our metabolic and gene-regulatory networks along with a database copy at the SYSTOMONAS website. 649 were here. azeeck@gwdg.de ; Institut für Organische und Biomolekulare Chemie, Georg‐ August‐Universität Göttingen Tammannstraße 2, 37077 Göttingen, Germany. ENZYME (17) and BioCyc (5) provide further functional characterization of proteins. Recombinant human antibodies are proven potent neutralizers of viruses and can block the interaction of viral surface proteins with their host receptors. Herzlich mit vielen Willkommens-Mails wurde Professor Dan Schürch im Department Architektur Technische Universität Braunschweig empfangen. The web server is Apache 2.0 (Author Webpage). * strain absent in KEGG (version 13th April 2006). : ++49 931-31-46168 Technische Universität Braunschweig Institut für Füge- und Schweißtechnik. Teaching Winter Semester 2020/2021; CS department TU Braunschweig 0313398A), BMBF for the Bioinformatics Competence Center Intergenomics (Grant No. Despite this importance, the molecular mechanisms mediating this process are only poorly understood in biological systems. The focus of SYSTOMONAS is on pseudomonads and in particular Pseudomonas aeruginosa, an opportunistic human pathogen. Technische Universität Braunschweig, Institut für Pharmazeutische Chemie, Beethovenstraße 55, 38106 Braunschweig, Germany Fax: +49‐531‐391‐2799===Search for more papers by this author Mikrobiologie; So finden Sie uns; Startseite; Home; Impressum; Datenschutz; Barrierefreiheit; Sitemap; suchen. Sehen Sie, wen Institut für Klinische Radiologie, Klinikum der Universität München, Munich, Germany für diese Position eingestellt hat. Logg Dich ein, um alle Einträge zu sehen. r.meine@tu-bs.de. Dr. Chris Carrie, Ludwig-Maximilians-Universität München Plant inner mitochondrial membrane insertion pathways 13.01.2016 Prof. Ludger Beerhues, Institut für Pharmazeutische Biologie, Technische Universität Braunschweig Biotechnology of active plant polyketide derivatives 2015. All necessary information concerning this reaction is provided by mouse click. Economics Department Working Paper Series, TU Braunschweig Ferit Küçükay Tagungsbeiträge . Metabolites measured from samples of exponentially growing cells under aerobic conditions are plotted along the x-axis against metabolites from samples of resting cells along the y-axis. Technische Universität Braunschweig Hans-Sommer-Straße 4 38106 Braunschweig Veröffentlichungen und Institutsberichte Prof. Dr.-Ing. Statistics of the metabolic network reconstruction for various Pseudomonas species in SYSTOMONAS. In order to improve the metabolic network reconstruction by applying another method, we also used the tool metaSHARK (1). Important Links . Diese entstehen unter anderem, wenn eine… Bildnachweis: IMN/TU Braunschweig. (1–3)], and for the generation of gene-regulatory networks (4), i.e. 38106 Braunschweig Professorin Dr. Christine Falk: Medizinische Hochschule Hannover (MHH) Institut für Transplantationsimmunologie Carl-Neuberg-Straße 1 30625 Hannover Professorin Dr. Nicole Frankenberg-Dinkel: Technische Universität Kaiserslautern Fachbereich Biologie Fachgebiet Mikrobiologie Paul-Ehrlich-Straße 23 67663 Kaiserslautern Professor Dr.-Ing. Here we focus on data integration for the biotechnologically and medically relevant group of bacteria, the pseudomonads. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only.